NDRG2 and infection: Next, the adenovirus carrying NDRG2 (Ad-NDRG2) or the siRNA targeting NDRG2 (NDRG2 siRNA) was applied to upregulate or knock down, respectively, the level of NDRG2. After infection by Ad-NDRG2 in SK-BR-3 or transfection by NDRG2 siRNA in T-47D cells, the expression of NDRG2 was successfully increased or decreased (Figure 2B).