The level of eosinophilia is seemingly a biomarker for asthma exacerbations.51, 52, 53, 54 Exposure of HDM- sensitized mice to Alternaria resulted in a dramatic augmentation of eosinophilic inflammation that was seemingly fungal intrinsic serine protease activity dependent and, therefore, potentially contingent on IL-33. The gene discussed is IL33; the disease is Increased total eosinophil count.