To further understand the role of EPCR in the pathogenesis of cerebral malaria, levels of endothelial expression of cell-bound and soluble forms of EPCR are required to be compared between cerebral and mild malaria patients, after adjustment for rs867186 genotype and expression levels of DC8 and DC13 PfEMP1 variants. The gene discussed is CMC2; the disease is cerebral malaria.