Previous studies suggest that inflammatory markers may play an important role in mediating the effects of PA on CHD in middle-aged populations,13,14,30 and the current study found that adjustment for CRP, vWF, and D-dimer (which have previously been linked to CHD risk4,9–11,31 and PA levels5,32) partially explained associations between PA and CHD. This evidence concerns the gene CRP and coronary artery disorder.