C-reactive protein (CRP), a marker of inflammation that is particularly strongly linked to fatal CHD in older adults,4 von Willebrand factor (vWF), a marker of endothelial dysfunction; D-dimer, a marker of fibrinolytic activity; and N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of cardiac injury, are all associated with PA levels5–8 and prospectively associated with CHD9–11 or cardiovascular disease (CVD)6 and heart failure12 in healthy older adults. The gene discussed is NPPB; the disease is coronary artery disorder.