When stimulated by EC-derived ANG-2, TEM additionally upregulate several pro-angiogenic factors including TP and cathepsin B. Moreover, ANG-2 induces the expression of IL-10 and CCL17 by TEM, factors which suppress T-cell proliferation and promote the expansion of regulatory T-cells providing tumor cells with a way to escape from immune responses (Coffelt et al., 2011). Here, ANGPT2 is linked to neoplasm.