We and others also found in several tumor models that stabilin-1 is expressed by TAM (Schledzewski et al., 2006; Werno et al., 2010; Algars et al., 2012; David et al., 2012), leading to the hypothesis that stabilin-1-mediated clearance of SPARC can affect tumor angiogenesis. This evidence concerns the gene SPARC and neoplasm.