TAM originate from circulating monocytes which are recruited to the tumor site and programmed by tumor-derived factors such as colony-stimulating factor-1 (CSF-1), vascular endothelial growth factor A (VEGF-A) and CC chemokine ligand 2 (CCL2) (Mantovani et al., 1992; Qian and Pollard, 2010). Here, VEGFA is linked to neoplasm.