The functional consequences of 15-LOX-1 suppression of hypoxia-induced HIF-1α upregulation are demonstrated in findings in this report, showing that 15-LOX-1 also inhibited prometastatic events [expression of VEGF (a HIF-1α transcriptional target), angiogenesis, and tumor cell invasion] that are driven by HIF-1α secondary to tumor microenvironment hypoxia 26–28; these findings support the role of 15-LOX-1 in suppressing metastases. Here, VEGFA is linked to neoplasm.