ALOX15 and malignant colon neoplasm: These findings demonstrate that 15-LOX-1 reexpression in colon cancer cells inhibits their survival not only under normoxic conditions, as we have published previously 6, but also under hypoxic conditions, suggesting that 15-LOX-1 loss in colon cancer cells 15 promotes not only the initial step of tumorigenesis, but also later steps when cells are selected under hypoxia pressure for their metastatic potential.