While differences in experimental modeling (e.g., HIF-1α, as a VEGF transcriptional driver, is induced by hypoxia in colon cancer cell lines, while PC-3 cells constitutively express HIF-1α without hypoxia 59) might have contributed to the contrasting results between our current results in colon cancer cell lines and the prior study of PC-3 prostate cancer cell line, our current results are more consistent with the studies in noncancer models and thus offer the unifying concept that 15-LOX-1 represses VEGF expression and angiogenesis in various disease entities. This evidence concerns the gene VEGFA and Familial prostate cancer.