The PRC2 methyltransferase EZH2 and its structural partners EED, SUZ12, and RBP7 are expressed at elevated levels in human HCC and contribute to tumorigenesis by silencing multiple miRNAs.24 The PRC2-regulated miR-125b is a transcriptional corepressor of the H3K9 methyltransferase SUV39H (Fig. 2), which regulates heterochromatin formation.25 SUV39H is overexpressed in human HCC and when knocked-down in HCC cell lines inhibits proliferation and migration. The gene discussed is SUZ12; the disease is hepatocellular carcinoma.