GRM1 and amyotrophic lateral sclerosis: We have previously identified mGluR1 receptors in triple negative breast cancer cells and have demonstrated that inhibiting mGluR1 activity with BAY36-7620 or Riluzole, at doses equivalent to doses already being used clinically in human beings to treat ALS, significantly inhibits the growth of MDA-MB-231 xenografts in mice [38].