The determination that JNK phosphorylation of Bim Ser69 is required for PIXosome assembly and LMP, together with the ability of cIAPs to regulate death receptor-induced JNK activation and apoptosis in liver cancer cells [15], [19], [34], led us to ask if cIAP inhibitors can block TRAIL-induced LMP by preventing Bim phosphorylation. Here, MAPK8 is linked to liver cancer.