The pathway cluster B contains pathways down-regulated in most of the subgroups associated with xmrk but up-regulated in the subgroups associated with kras and Myc. Interestingly, theses pathways were consistent with highly down-regulated pathways in the xmrk-induced zebrafish HCC, including energy metabolism, amino acid metabolism, fatty acid metabolism, bile acid biosynthesis, complement pathway, biosynthesis of steroid, and N-glycan biosynthesis. Here, KRAS is linked to hepatocellular carcinoma.