CD4 and tuberous sclerosis: In addition, recent thymic emigrants (CD45RA+CD62LhighCD31+, not shown) and mature T cells with naïve (Naïve: CD45RA+ CD27high), central memory (CM: CD45RA− CD27high), effector memory (EM: CD45RA− CD27low) and terminal differentiated effector (EF: CD45RA+ CD27low) phenotypes were all similarly represented among both CD4+ and CD8+ T cell subsets of TSC subjects (Figure 1C, D, E), with the exception of terminal differentiated CD8+ effector cells, which appeared to be significantly reduced in frequency in TSC1 subjects.