In the older population, negative associations were observed between ALT increment and all-cause, CV disease-related, cancer-related mortality (HR: 0.91, 95% CI: 0.88–0.94, for all-cause mortality; HR: 0.91, 95% CI: 0.85–0.96, for CV disease-related mortality; HR: 0.92, 95% CI: 0.86–0.98, for cancer-related mortality). This evidence concerns the gene GPT and cancer.