In addition, 11 regulation targets (ANXA8, CTSH, CTSK, GSTP1, HSP90AA1, IL6, MYO6, PERP, PHLDA3, PRDX3, and PSEN2) of TP53 showed differential expression in both PA and CT HB compared with IVV HB. The gene discussed is CTSK; the disease is hemoglobin measurement.