In addition, 11 regulation targets (ANXA8, CTSH, CTSK, GSTP1, HSP90AA1, IL6, MYO6, PERP, PHLDA3, PRDX3, and PSEN2) of TP53 showed differential expression in both PA and CT HB compared with IVV HB. This evidence concerns the gene ANXA8 and hemoglobin measurement.