In comparison with IVV HB, the“eIF2 signalling”, “mTOR signalling”, “regulation of eIF4 and p70S6K signalling”, “mitochondrial dysfunction”, and “protein ubiquitination pathway” pathways were the 5 most significantly altered pathways in PA HB, and most of the differentially expressed genes associated with these 5 pathways were down-regulated in PA HB. Here, RPS6KB1 is linked to hemoglobin measurement.