POMC and periventricular leukomalacia: Figure 2 shows that although the with-hemorrhage PVL rats tended to have higher corticosterone levels before and after ACTH injection as compared with the without-hemorrhage PVL rats, they did not reach the statistical significance (with- vs. without-hemorrhage (ng/ml): before ACTH: 336.7±21.0 vs. 288.3±25.1, P = 0.153; after ACTH: 391.3±14.7 vs. 344.4±26.8, P = 0.145).