However, markers for GBM that have prognostic value in signaling transduction pathways have not been fully elucidated yet.The Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathways transmits extracellular signals into the nucleus where it regulates DNA transcription and activity in the cell[6]. Here, STAT3 is linked to glioblastoma.