CXCR3 and Guillain-Barre syndrome: CXCL10/CXCR3 signaling has also been implicated in GBS pathogenesis based on a report that demonstrated elevated CSF CXCL10 levels in GBS patients compared to controls, with CXCL10 messenger RNA co-localized to peripheral nerve vascular endothelium using in situ hybridization techniques [38].