FD apparently activated this presynaptic pathway by elevating the key transcriptomic members, including nSHC (also known as SHC3), NMDAR2A (also known as GRIN2A) and CACNA1A. Promoting the excitatory against the inhibitory synaptic transmissions [70], CACNA1A contributes to a number of neurological disorders [71]. This evidence concerns the gene SHC3 and nervous system disorder.