In contrast, the methylation of heparanase had no apparent associations with the following prognostic factors: tumor size (p = 0.078), node metastasis (p = 0.133), ER positivity (p = 0.101), PgR positivity (p = 0.528), and HER2 expression (p = 0.196). The gene discussed is HPSE; the disease is neoplasm.