Further, while HDM exposure did not result in a classical TH2 driven response (such as BAL eosinophilia), there were significant effects of HDM exposure on most parameters measured, including increased cellular inflammation (primarily macrophages and neutrophils), AHR, increased lung tissue responsiveness, and increased total IgE and HDM-specific IgG1. This evidence concerns the gene AHR and Increased total eosinophil count.