Some genes were closely related to the malignant phenotype of the tumor, such as IGF1, CXCR7, TCF3, NPR1, FGF18, DDR2, GLI2, CYR61, COL14A1, HSPH1, SOX11, TRIB2, PDZK1, and MMP2. This evidence concerns the gene ACKR3 and neoplasm.