In our murine experiments there was no fractalkine production and no ESX1-mediated difference in cellular recruitment of CD11b+ or CD3+ cells into the murine lung, suggesting this artificial model system which lacks granuloma formation and which, unlike the zebrafish-M. marinum model, is not a natural host/pathogen pair, is substantially different to human infection. The gene discussed is CX3CL1; the disease is infection.