Generally, high serum PFAS levels was a consistent risk factor of BC, and in combination with having at least one variant CYP1A1 Val allele, or one variant COMT Met allele, or the common CYP17 A1 allele, the PFAS-associated BC risk increased, indicating that these polymorphisms can act as modulators of the development of BC related to environmental exposure. This evidence concerns the gene COMT and breast cancer.