COMT and breast cancer: A study investigating the combined effect of high-risk genes for CYP1B1, COMT, glutathione S-transferase pi (GSTP1) and manganese superoxide dismutase (MnSOD) on BC risk in Caucasian postmenopausal women reported that the presence of both the CYP1B1 high activity Val and COMT low activity Met was associated with an increased risk of BC (OR 2.0, 95% CI 1.1–3.5) [55].