Interestingly, Orr et al. [29] recently found that EGF can induce ezrin phosphorylation (Thr567) via activation of the SK/S1P pathway, and Antelmi et al. [30] revealed that p-ezrin was almost exclusively expressed in invadopodia lipid rafts where it co-locolized in a functional complex with EGFR and β1-integrin in metastatic breast cancer cell line MDA-MB-231, suggesting that ezrin might be related with EGF and EGFR in cancer progression. This evidence concerns the gene EGF and breast cancer.