BRCA1 and ovarian cancer: In this study, we report for the first time an association between BRCA1 and GR status in ovarian cancer: (i) the BRCA1 inactivation group showed dramatically decreased expression of GR compared with adjacent normal tissue; (ii) there was a positive correlation between BRCA1 and GR expression in human ovarian cancer specimens; (iii) BRCA1 knockdown was effective at inhibiting GR expression, and overexpression of BRCA1 induces an increase in GR levels in ovarian cancer cells.