In this study, we report for the first time an association between BRCA1 and GR status in ovarian cancer: (i) the BRCA1 inactivation group showed dramatically decreased expression of GR compared with adjacent normal tissue; (ii) there was a positive correlation between BRCA1 and GR expression in human ovarian cancer specimens; (iii) BRCA1 knockdown was effective at inhibiting GR expression, and overexpression of BRCA1 induces an increase in GR levels in ovarian cancer cells. This evidence concerns the gene NR3C1 and ovarian cancer.