In addition, emerging evidence has suggested that: (i) both genetic and environmental factors contribute to impaired GR function[8]; (ii) GR inactivation is a hallmark for BRCA1-mutated breast cancer tissues[9]; and (iii) the BRCA1-interacting protein NELF-B participates in GR-mediated gene induction[10]. This evidence concerns the gene NR3C1 and breast cancer.