NFKB1 and neoplasm: As the function of the stroma in the tumor microenvironment has been underestimated for many years, it has been reported that stromal cell-related cytokines of inflammation such as tumor necrosis factor alpha (TNF-α) activate nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) play important but as yet unquantified roles in tumor development [39,40].