PAX8 and large cell carcinoma: In order to validate the expression of PAX8 in NSCLC tumors, we determined PAX8 protein expression using TMA (Tissue Microarray) which represents archival NSCLC tumor tissues and carried out IHC analysis of PAX8 expression in adeno carcinoma (n = 94), Large cell carcinoma (85), squamous cell carcinoma (47), and metastatic tumor tissue samples (28) are shown in Figure 1.