To further investigate the mechanism, we found that FOXM1 performed a crucial role in docetaxel-resistant gastric cancer cells by directly targeting and up-regulating the microtubule-destabilizing protein Stathmin, which partially rescued FOXM1-knockdown inhibitory effect on docetaxel resistance, and then inhibiting the polymerization of tubulin. The gene discussed is STMN1; the disease is gastric cancer.