ACTB and Alzheimer disease: In this study, we also looked for the identification of cerebrospinal fluid (CSF) and plasma based AD specific biomarker and found 3 common proteins (APOE, EGFR, ACTB) among 108 AD proteins and proteins from CSF and plasma proteome (Figure 6) and 38 common proteins among 640 putative AD proteins and proteins from CSF and plasma proteome (Additional file 7), which might serve as potential biochemical biomarkers for early detection of AD cases in future.