However, as to the best of our knowledge, this study represents the first whole-transcriptome analysis specifically focusing on coronary artery calcification, and differentially genes that we found include many previous CAD candidates (such as MMP7, EPAS1, ESAM, CASP1, GUCY1A3, CLCN4, LEF1, ENPP5, and ZHX2), some observations may be relevant to state here. The gene discussed is ENPP5; the disease is coronary artery disorder.