Therefore, copeptin, as a surrogate marker of this system, might also be associated with disrupted glucose homeostasis: a recent study demonstrated that increased copeptin levels were found to be associated with prevalent DM at baseline (p = 0.04) and insulin resistance (p < 0.001) in a large population of 4742 subjects (cross-sectionally) [30]. The gene discussed is AVP; the disease is diabetes mellitus.