The miR-183/96/182 cluster may provide an explanation to this puzzle, inasmuch as miR-183 has been demonstrated to target the tumor suppressor gene, EGR1, and participate in a miR-183-EGR1-PTEN network that promotes tumorigenesis and cell migration in synovial sarcoma, rhabdomyosarcoma, and colon cancer [19]. This evidence concerns the gene EGR1 and malignant colon neoplasm.