Although no evidence on possible redox reactions, namely, S-nitrosation, have been provided yet on TRIM2, it is plausible that its occurrence could inhibit TRIM2 activity, as already demonstrated for many other members of the ubiquitin E3 ligase superfamily, thereby allowing speculating that the existence of an S-nitrosated form of TRIM2 could correlate with the onset of axonopathy and muscle atrophy-associated peripheral neuropathy. The gene discussed is TRIM2; the disease is peripheral neuropathy.