RUNX2 and neoplasm: In contrast to these putative tumour-suppressor properties, all three genes promote lymphoma development in mice (Cameron and Neil, 2004; Castilla et al., 2004; Stewart et al., 1997), a pro-oncogenic function confirmed for Runx1 and Runx2 using transgenic models (Blyth et al., 2009; Blyth et al., 2001; Vaillant et al., 1999).