Interestingly, RUNX2 has never been identified in transcriptomic analyses of breast cancer, but this might be due to problems with RUNX2 probe sets, and, using a RUNX2 metagene as a surrogate for RUNX2 activity, it has been shown that high expression of RUNX2-target genes correlates with basal-like breast cancers (Chimge and Frenkel, 2013), in support of our own conclusions. The gene discussed is RUNX2; the disease is breast carcinoma.