LETM1 and Wolf-Hirschhorn syndrome: LETM1 is a highly attractive contributing candidate for seizures in WHS principally because of its demonstrated role in various aspects of mitochondrial homeostasis (Dimmer et al., 2008; Endele et al., 1999; Hasegawa and van der Bliek, 2007; McQuibban et al., 2010; Nowikovsky et al., 2004; Tamai et al., 2008).