Furthermore, CTBP1 and/or CPLX1 haploinsufficiency, two genes telomeric to LETM1, have also been proposed to possibly underlie seizures in WHS, although, again, without any supportive, associative functional cellular characterization in WHS-patient cell lines (Misceo et al., 2012; Simon and Bergemann, 2008). Here, CPLX1 is linked to Wolf-Hirschhorn syndrome.