For example, we recently identified delayed S-phase progression and impaired chromatin remodelling in WHS-patient LCLs attributable to haploinsufficiency of SLBP and/or WHSC2 (NELF-A); phenotypes with implications for the maintenance of epigenetic memory, expansion of stem cell niches, and possibly microcephaly and growth retardation (Kerzendorfer et al., 2012). This evidence concerns the gene NELFA and microcephaly.