YY1 is a transcription factor that also has documented roles in either enhancing or repressing gene expression in multiple cancers [40]–[42], however its tumorigenic overexpression and prognostic value have been the subject of debate due to conflicting reports for multiple cancers, including in breast, colon, prostate, osteosarcoma, cervical and ovarian cancers [42]. Here, YY1 is linked to osteosarcoma.