The results presented here are consistent with the study of Volbrecht et al. demonstrating an expansion of CD15+ CD33+/dim CD11b+ G-MDSC population in HIV-1 infection [27] and with the studies by Cloke et al. describing a population of activated low-density granulocytes/neutrophils (LDNs) in PBMCs of HIV-1-infected patients [28], [46]. Here, CD33 is linked to HIV-1 infection.