Notwithstanding these changes reported to occur in prenatal cocaine-exposed brains, we propose that hyper-activation of PKC resulting in sustained phosphorylation of mGluR1s and the consequent uncoupling of mGluR1 from Homer1 and Gq/11 elucidated here may be one of the prominent events underlying prenatal cocaine-induced cognitive impairment. Here, GRM1 is linked to Cognitive impairment.