CASP1 and infection: As shown in Figure 1A, infection of macrophages with MOI 50 resulted in a strong cleavage signal of caspases-1, -7 and PARP and a moderate activation of caspase-9 by B. pseudomallei strain E8, whereas processing was much less in response to B. pseudomallei strains K96243, 1026b, and E212.