We found that early processing of caspase-1 (Figures 6, 8A, 9A), induction of pyroptosis (Figures 8C, 9C) and secretion of IL-1β (Figures 8D, 9D) were reduced after infection of BMM with a B. pseudomallei flagellin FliC mutant. The gene discussed is CASP1; the disease is infection.