CASP1 and infection: In line with our previous study [29], we observed no differences in LDH release within 6 hours after infection at low MOI between caspase-1/11-deficient and wild-type macrophages (Figure 2C), but a 10-fold higher bacterial burden in cells lacking caspase-1/11 (Figure 2B) indicating that caspase-1-dependent effector functions might contribute to the control of B. pseudomallei intracellular replication.