PYCARD and Familial prostate cancer: Several are known biomarkers for diagnosis and prognosis of prostate cancer (APC, GSTP1, KIT, PYCARD, PGDGRB, RARB, RARRES1, and TIMP1) [35], [36], [37], [38], [39], [40] and some though not biomarkers, were found to be dysregulated in the disease (CDKN1B, MMP7, and MMP9) [41].