Majority of the genes were previously implicated in prostate cancer, such as: ALOX12, APC, CDKN1B, EPHA2, GSTP1, KIT, MMP7 MMP9, PDGFRB, PYCARD, RARA, RARB, RARRES1, and TIMP1[32], [33], [34]. This evidence concerns the gene TIMP1 and Familial prostate cancer.