XIAP and neoplasm: To explore further the functionality of apoptosome apparatus in NSCLC, we studied its sensitivity to activation in the cell-free cytosol from NSCLC cells and NSCLC tumours and matched lungs, the assembly of apoptosome complexes and functional stability apoptosome precursors, the impact of clinico-pathological parameters of NSCLC tumours on the level of apoptosome-generated CS-3-like activity, and the involvement of XIAP in the regulation of apoptosome activity in NSCLC tumours.