PSMD14 and Intellectual disability: However, also PSMD14 and NUP205 proved to be attractive candidate genes: The human deubiquitinase and constituent of the proteasome complex PSMD14 was previously found to be one of three candidate genes within a critical region on 2q24 where CNVs have been linked to intellectual disability [12] and - like multiple other genes associated with autism-like phenotypes – might have a role in proteasome-mediated synapse elimination.