Because EGFR activation mediates resistance to chemotherapy and apoptosis by activating the mitogen activated protein kinases (MAPK) and phosphoinositide 3-kinase (PI3-K)/AKT-dependent survival pathways [225], the presence of different species of GM3 in tumours could explain the controversial role of this ganglioside in apoptosis, as the experimental data have shown. Here, AKT1 is linked to neoplasm.