In renal carcinoma cells, the enrichment of ganglio-series gangliosides, in particular GD1a (αNeu5Ac(2-3)βGal(1-3)βGalNAc(1-4)αNeuu5Ac (2-3)βGal(1-4)βGlc(1-1)Cer), to the detriment of globo-series gangliosides, changes the functionality of plasma membrane caveolae and increases the endocytosis and lysosomal degradation of β1 integrin and epidermal growth factor receptor (EGFR) [190]. The gene discussed is EGFR; the disease is renal carcinoma.