Some recent papers demonstrated that the treatment of cancer cells with the TNFα-related apoptosis inducing ligand (TRAIL) induces the redistribution of TRAIL death receptor 1 (DR4) and TRAIL death receptor 2 (DR5) into lipid rafts and, thus, triggers apoptosis through the activation of caspases 8 and 10 [184–186]. This evidence concerns the gene TNFRSF10B and cancer.