In particular, the accumulation of de novo synthesised Cer is crucial for cannabinoid-triggered ER stress and apoptosis in these cells [73,97], and the accumulation of Cer in the ER owing to impaired Cer traffic is associated with the antiproliferative effect of nitric oxide [98], which suggests that Cer levels in the ER can be crucial for glioma cell fate. Here, CBLN1 is linked to central nervous system cancer.