ST3GAL5 and Carcinoma, Lewis Lung: Similarly, transfection of the GM3 synthase (SAT-I) cDNA into J5 cells, which are GM3-deficient clones of the murine 3LL Lewis lung carcinoma cell line [216], gives rise to enhanced resistance to etoposide and doxorubicin-induced apoptosis mainly owing to the over-expression of BCL-2 [217].