The reason that the serum HDL-C level serves as a prognosis factor for NSCLC may be mainly attributed to its pleiotropic properties, including antioxidative function, inhibition of cytokine-induced expression of endothelial cell adhesion molecules, and suppression of the chemotactic activity of monocytes and lymphocytes [32], [33]. This evidence concerns the gene ESAM and non-small cell lung carcinoma.