Polymorphism in genes coding for tumor necrosis factor alpha (TNFα), mannan-binding lectin 2 (MBL2), Cytotoxic T-Lymphocyte Antigen 4 (CTLA4), transforming growth factor β (TGFβ), DC-SIGN, and human leukocyte antigen (HLA) class I and II alleles have been linked with an increased risk of severe dengue complications [8]. The gene discussed is TNF; the disease is dengue disease.