In particular NK cells in the liver and the tumour were relatively KIR (killer immunoglobulin-like receptor) lo (median% of NK cells expressing KIR2DL1 and KIR2DL2/3 in: liver 4.5% and 15.1%, tumour 3.1% and 13.5%, peripheral blood 25% and 36.7%) and NKG2Ahi (median% of NK cells expressing NKG2A: liver 65%, tumour 65%, peripheral blood 46%) when compared with NK cells isolated from peripheral blood (Figure 3). Here, KLRC1 is linked to neoplasm.