However NKG2D expression was maintained on NK cells isolated from peripheral blood of patients with colorectal liver metastases (median% of NK cells expressing NKG2D from peripheral blood of patients with metastases 81.6% vs healthy volunteers 84.9%, p = 0.98), and also on the tumour infiltrating NK cells (median 92.6%) indicating that NKG2D downregulation was not a cause for the weak NK cell response (Figure 4). The gene discussed is KLRK1; the disease is neoplasm.