A recent clinical validation performed on RNA extracted from over 1000 FFPE tumor specimens from the ATAC clinical trial demonstrated that the Prosigna risk of recurrence (ROR) score, based on the PAM50 gene expression signature, added significant prognostic information beyond the Oncotype DX® Recurrence Score® in estimating the likelihood of distant recurrence in hormone receptor positive, post-menopausal breast cancer patients [19] treated with endocrine therapy alone. Here, NR4A1 is linked to breast carcinoma.