Our results showed that patients with homozygous genotypes also showed higher CR rate than heterozygous genotype in non-GCB DLBCL but not in GCB DLBCL subgroup, which was consistent with previous reports that the activation of STAT3 plays a more important role in ABC-DLBCL than GCB-DLBCL [18,19]. This evidence concerns the gene STAT3 and aneurysmal bone cyst.