Across all classification systems, age, age at diabetes diagnosis, diabetes duration, HbA1c, percentage of insulin users, triglycerides, non-HDL cholesterol, systolic BP, prevalence of dyslipidemia, hypertension, lipid-lowering therapy, and anti-hypertensive treatment (including usage of blockers of the renin-angiotensin system), BMI, and waist circumference tended to increase, whereas HDL cholesterol and, except in the AKDN system, percentage of current smokers decreased. This evidence concerns the gene REN and diabetes mellitus.