This anti-tumor effect is thought to be driven by the inhibition of cyclooxygenases [COX-2, officially called HGNC:9605 or PTGS2 (prostaglandin-endoperoxide synthase 2)], interacting with the arachidonic acid metabolite pathway, however, the detailed mechanism of action is not completely understood [reviewed in Ref. This evidence concerns the gene PTGS2 and neoplasm.