PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), the catalytic p110-alpha subunit of PI3K, has been described to be commonly mutated in various cancer, including glioblastoma, gastric, breast, ovary, lung, and CRC (7, 8). The gene discussed is PIK3CA; the disease is colorectal carcinoma.