We showed that the Trx1 mimetic peptides CB3 known to inhibit JNK and p38MAPK phosphorylation in fibroblasts [29], neuroendorine PC12 [26], and INS 832/13 insulinoma cells [27], prevented apoptosis in human neuroblastoma SH-SY5Y cells. This evidence concerns the gene TXN and pancreatic insulinoma.